Journal
RESEARCH IN PHARMACEUTICAL SCIENCES
Volume 15, Issue 2, Pages 107-122Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1735-5362.283811
Keywords
Aptamer; Biosensor; Cancer detection; Tumor marker
Categories
Funding
- Isfahan University of Medical Science [396391]
- Biotechnology Development Council of the Islamic Republic of Iran [960304]
Ask authors/readers for more resources
Cancer is typically associated with abnormal production of various tumor-specific molecules known as tumor markers. Probing these markers by utilizing efficient approaches could be beneficial for cancer diagnosis. The current widely-used biorecognition probes, antibodies, suffer from some undeniable shortcomings. Fortunately, novel oligonucleotide-based molecular probes named aptamers are being emerged as alternative detection tools with distinctive advantages compared to antibodies. All of the existing strategies in cancer diagnostics, including those of in vitro detection, can potentially implement aptamers as the detecting moiety. Several studies have been performed in the field of in vitro cancer detection over the last decade. In order to direct future studies, it is necessary to comprehensively summarize and review the current status of the field. Most previous studies involve only a few cancer diagnostic strategies. Here, we thoroughly review recent significant advances on the applications of aptamer in various in vitro detection strategies. Furthermore, we will discuss the status of diagnostic aptamers in clinical trials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available