Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 21, Issue 29, Pages 4342-4354Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612821666150901104821
Keywords
Self-assembly; peptide hydrogel; drug delivery; hydrogelator; biomaterials
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Funding
- Natural Science Foundation of China (NSFC) [51403042, 31370781]
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council)
- Institute of Bioengineering and Nanotechnology (Agency for Science, Technology and Research, Singapore)
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Molecular hydrogels have been widely explored in various biomedical applications, such as cell culture, tissue engineering and drug delivery. Peptide-based hydrogel nanoparticles represent a promising alternative to current drug delivery approaches and cell carriers for tissue engineering, due to their encapsulation stability, water solubility and biocompatibility. This review focuses on recent advances in the use of self-assembling peptide nanogels for applications in drug delivery. We firstly introduce a self-assembly mechanism for small molecules used in the peptide hydrogel, and then describe recent methods for controlling the assembly of molecular hydrogelations. A particular emphasis is placed on recent advances in the use of different types of peptide hydrogels as drug delivery carriers. Lastly, the current challenges and future perspectives for self-assembling peptide hydrogels in drug delivery applications are discussed.
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