Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 21, Issue 14, Pages 1785-1799Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612821666150304161201
Keywords
Human serum albumin; anti-bacterial drugs; anti-cancer drugs; protein-drug interaction
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Funding
- University Grants Commission (New Delhi, India)
- Internal funds of Biotechnology, AMU Aligarh
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Human serum albumin (HSA) is the most important carrier of exogenous and endogenous molecules in human plasma. Understanding and characterizing the interaction of drugs with HSA has attracted enormous research interests from decades. The nature and magnitude of these bindings have direct consequence on drug delivery, pharmacokinetics, pharmacodynamics, therapeutic efficacy and drug designing. An overview of HSA and anti-bacterial/anti-cancer ligands interaction is the need of the hour as these drugs together constitute more than half of the total drug consumption in the world. In this review, the information on the number of binding sites, binding strength, the nature of binding interactions and the location of binding sites of such drugs on the HSA are summarised. The effect of such drugs on the overall conformation, stability and function of HSA is also reviewed. This review will help to gain useful insights into the significance of the binding of anti-bacterial and anti-cancer drugs with plasma protein and the effect of binding on its overall distribution and pharmacological activities.
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