Journal
RSC ADVANCES
Volume 10, Issue 32, Pages 19067-19075Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra02226h
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Funding
- National Natural Science Foundation of China [21572268]
- National Science and Technology Major Project of China [2018ZX09711003-003-001]
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10-23 DNAzyme has been extensively explored as a therapeutic and biotechnological tool, as well as in DNA computing. Faster cleavage or transformation is always needed. The present research displays a rational modification approach for a more efficient DNAzyme. In the catalytic core, amino, guanidinium and imidazolyl groups were introduced for its chemical activation through the adenine base. Among the six adenine residues, A9 is the unique residue that realizes all the positive effects; the 6-amino and 8-position of adenine and the 7-position of 8-aza-7-deaza-adenine could be used for the introduction of the functional groups. A12 is a new choice for catalytic improvement with an 8-substituent. Therefore, more active DNAzymes could be expected by this nucleobase-modified activation approach.
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