Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 21, Issue 10, Pages 1272-1278Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612821666141211145610
Keywords
Epigenetic regulation; hypoxia; epithelial-mesenchymal transition; HIF-1 alpha; chromatin modifier; co-regulator; target
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Funding
- National Natural Science Foundation of China [81301850]
- Educational Commission of Zhejiang Province of China [Y201328812]
- Ministry of Science and Technology Summit grant [MOST 103-2745-B-039-001-ASP]
- National Science Council Frontier grant [NSC102-2321-B-010-001]
- Kee-lung Chang-Gang Memorial Hospital [CMRPG2D0031]
- National Research Program for Biopharmaceuticals [NSC102-2325-B-010-004]
- Ministry of Education, Aim for the Top University Plan [103AC-T301]
- Health and welfare surcharge of tobacco products [MOHW103-TD-B-111-02]
- National Health Research Institutes [NHRI-EX103-10230SI]
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Intratumoral hypoxia followed by stabilization/activation of hypoxia-inducible factor 1 (HIF-1) and its downstream transcriptional factors, is one of the most important mechanisms inducing epithelial-mesenchymal transition (EMT), which has been widely accepted as a crucial step to generate early stage of tumor metastasis. Accumulating evidence suggests that epigenetic mechanisms play important roles in hypoxia-induced EMT and metastasis. These epigenetic regulations are mediated by various players including chromatin modifiers, transcriptional co-regulators, microRNAs, etc. In this review, we discuss how his tone-modifying enzymes and transcriptional co-regulators regulate EMT under hypoxic conditions. Developed or potential anticancer agents targeting epigenetic molecules regulating hypoxia-induced EMT are also discussed.
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