Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 21, Issue 21, Pages 3032-3040Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612821666150514105741
Keywords
Epithelial-mesenchymal transition; inflammation; metastasis
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Funding
- NIH (RO1s) [CA125454, CA188118]
- DOD Breakthrough Award [BC140733P1]
- Mary Kay Ash Foundation
- National Natural Science Foundation of China [81402432]
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Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.
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