Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 21, Pages 4000-4003Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob00972e
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Funding
- EPSRC [EP/M028127/1, EP/S013741/1, 1799721, EP/K039660/1] Funding Source: UKRI
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The alpha-oxo aldehyde is a highly reactive aldehyde for which many protein bioconjugation strategies exist. Here, we explore the genetic incorporation of a threonine-lysine dipeptide into proteins, harbouring a masked alpha-oxo aldehyde that is rapidly unveiled in four minutes. The reactive aldehyde could undergo site-specific protein modification by SPANC ligation.
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