Journal
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Volume 16, Issue 2, Pages 128-136Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920101602150112151157
Keywords
Antibacterial activity; biocompatibility; chitosan; drug delivery; nanoparticles; wound dressing
Funding
- UEFISCDI through project: Innovative dental products with multiple applications [PN-II-PT-PCCA-2013-4-0891, 229/2014]
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Owing to its physico-chemical characteristics, the biodegradable and biocompatible polymer derived from crustacean shells, Chitosan is one of the preferred candidates for green biomedical applications and also for several industries. Its solubility in acid solutions and ability to form complexes with anionic macromolecules to yield nanoparticles, microparticles and hydrogels, as well as the ability of chitosan based nanocomposites to remain stable at physiological pH recommend this polymer for the development of efficient drug delivery systems. This paper reviews the main utilities of chitosan as a drug delivery component and describes the most recent technologies which utilize this polymer for developing nanostructured systems with antimicrobial effect, offering a perspective of using these findings in new, ecological biomedical applications.
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