Journal
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
Volume 16, Issue 8, Pages 733-737Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201016666150505121951
Keywords
Anti-biofilm activity; Anti-quorum sensing effects; Flavonoids; Pseudomonas aeruginosa PAO1
Funding
- Ministry of Education, Science and Technological Development of the Republic of Serbia [173032, 172015, 172053]
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This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/using the strain Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm formation (95%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known for its resistance.
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