Journal
JOURNAL OF ANALYSIS AND TESTING
Volume 4, Issue 3, Pages 198-209Publisher
SPRINGER SINGAPORE PTE LTD
DOI: 10.1007/s41664-020-00138-9
Keywords
Single cell; Metabolomics; Mass spectrometry; Recent advances
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Funding
- National Key Research and Development Program of China [2019YFC1605100]
- DICP, CAS [DICPQIBEBT UN201806]
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Metabolomics at the single-cell level can analyze cellular metabolites, study the phenotypic variations in individual cells and reveal phenomena and mechanisms that cannot be observed by analyzing large number of cells. It also provides an efficient way to study the dynamically changing metabolites and intermediates in single living cells. Microfluidics enables high-throughput analysis of single cells without disturbing cell metabolism as much as possible. Mass spectrometry is a promising tool for single-cell metabolomics and its innovation provides rich information of metabolites for single-cell analysis. In this mini-review, the recent new advances of single-cell metabolomics based on microfluidics and mass spectrometry in last five years are reviewed and prospected.
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