Journal
CHEMICAL SCIENCE
Volume 11, Issue 23, Pages 5889-5894Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc01273d
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Funding
- Recruitment Program for Young Professionals
- Research Program of State Key Laboratory of Bioreactor Engineering
- Fundamental Research Funds for the Central Universities
- NSFC [81974273]
- NSFC-BRICS [81861148020]
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Reported herein is a self-immobilizing near-infrared fluorogenic probe that can be used to image extracellular enzyme activity in vivo. Using a fluorophore as a quinone methide precursor, this probe covalently anchors at sites of activation and greatly enhances the fluorescence intensity at 710 nm upon enzymatic stimulus, significantly boosting detection sensitivity in a highly dynamic in vivo system.
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