Journal
BIOMATERIALS SCIENCE
Volume 8, Issue 11, Pages 3021-3025Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0bm00331j
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Funding
- National Natural Science Foundation of China [81772449, 21877130, U1801681]
- Fundamental Research Funds for the Central Universities [18ykpy31]
- Innovation and Technology Fund of Shenzhen [JCYJ20180214155856251, JCYJ20170818164356675, JCYJ20180307154611145]
- Innovation and Technology Fund of Guangzhou [201803010090]
- Key Field Research and Development Program of Guangdong Province [2018B030337001, 2019B020235001]
- Helmholtz-University Young Investigators Grant [VH-NG-621]
- Biointerfaces program at the Karlsruhe Institute of Technology (KIT)
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A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity.
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