Journal
BIOMATERIALS SCIENCE
Volume 8, Issue 11, Pages 3138-3146Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0bm00376j
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Funding
- National Natural Science Foundation of China (NSFC) [81972081, 51973226, 51803188]
- Special Scientific Research Project of Military Health Care [17BJZ15]
- Military Medical Science and Technology Youth Cultivation Project [20QNPY109]
- Military Medical Youth Growth Program of PLA General Hospital [QNC19028]
- Beijing Novel Program [Z181100006218059]
- China Postdoctoral Science Foundation [2019T120636, 2018M642783]
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Pharmacotherapy for hypercalcemia, which is mainly caused by osteoporosis, is an effective method to regulate the in vivo calcium equilibrium. From this perspective, the development of a minimally invasive gelling system for the prolonged local delivery of bisphosphonates has practical significance in the clinical therapy of bone osteoporosis. Here, a biocompatible and injectable hydrogel based on a uniform tetra-PEG network carrying a PEG-modified alendronate (ALN) prodrug for the localized elution and long-term sustained release of anti-osteoporotic small molecule drugs is reported. The obtained ALN-based tetra-PEG hydrogels exhibit rapid gel formation and excellent injectability, thereby allowing for the easy injection and consequent adaptation of hydrogels into the bone defects with irregular shapes, which promotes the ALN-based tetra-PEG hydrogels with depot formulation capacity for governing the on-demand release of ALN drugs and local reinforcement of bone osteoporosis at the implantation sites of animals. The findings imply that these injectable hydrogels mediate the optimized release of therapeutic cargoes and effectively promote in situ bone regeneration via minimally invasive procedures, which is effective for clinical osteoporosis therapy.
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