Journal
ZOOLOGICAL RESEARCH
Volume 41, Issue 3, Pages 220-230Publisher
SCIENCE PRESS
DOI: 10.24272/j.issn.2095-8137.2020.042
Keywords
Ischemia/reperfusion; Ferroptosis; Reactive oxygen species; Lipid peroxidation; Iron
Categories
Funding
- Ministry of Science and Technology of China [2018YFC1312300]
- National Natural Science Foundation of China [81722016, 81801182]
- Sichuan Science and Technology Program [2018JPT0037, 2018SZ0190]
- China Postdoctoral Science Foundation [2017M623041]
Ask authors/readers for more resources
Ischemia/reperfusion (I/R) is a pathological process that occurs in numerous organs throughout the human body, and it is frequently associated with severe cellular damage and death. Recently it has emerged that ferroptosis, a new form of regulated cell death that is caused by iron-dependent lipid peroxidation, plays a significantly detrimental role in many I/R models. In this review, we aim to revise the pathological process of I/R and then explore the molecular pathogenesis of ferroptosis. Furthermore, we aim to evaluate the role that ferroptosis plays in I/R, providing evidence to support the targeting of ferroptosis in the I/R pathway may present as a therapeutic intervention to alleviate ischemia/reperfusion injury (IRI) associated cell damage and death.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available