Journal
RSC ADVANCES
Volume 10, Issue 41, Pages 24159-24168Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra03442h
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- Deanship of Scientific Research at Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia
- Suez Canal University, Ismailia, Egypt
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The chemical and biological profiling of the root extracts ofRubia tinctorumwas performed. The activities of different extracts were determined considering the antidiabetic effect against type II diabetes mellitus together with anti-obesity and hepatoprotective effects and lipid profile. The methanolic extract ofRubia tinctorumexhibited significant results in decreasing body weight, improving lipid profile, normalizing hyperglycaemia, insulin resistance, hyperinsulinemia. Additionally, it showed enhancement of liver tissue structure and function. The methanolic extract, being the most significant one, was subjected to LC-HRMS analysis to determine its chemical constituents. Finally, the chemical constituents were evaluated by molecular docking study that was carried out to identify the interaction of a panel of 45 compoundsin silicoand to correlate the structures to their anti-diabetic activity. Among the tested compounds, 1-hydroxy-2-hydroxymethyl anthra-quinone and naringenin-7-O-glucoside showed the most potent activity as alpha-amylase inhibitors.
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