Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 34, Issue -, Pages 35-42Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.06.004
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [26110719]
- Japan Society for the Promotion of Science, Japan [25670018, 24590071, 25860037]
- Research Institute of Meijo University (Innovative Scientific Research Subsidy)
- Grants-in-Aid for Scientific Research [26110719, 25670018, 24590071, 25860037] Funding Source: KAKEN
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Recent functional studies on chondroitin sulfate-dermatan sulfate (CS-DS) demonstrated its indispensable roles in various biological events including brain development and cancer. CS-DS proteoglycans exert their physiological activity through interactions with specific proteins including growth factors, cell surface receptors, and matrix proteins. The characterization of these interactions is essential for regulating the biological functions of CS-DS proteoglycans. Although amino acid sequences on the bioactive proteins required for these interactions have already been elucidated, the specific saccharide sequences involved in the binding of CS-DS to target proteins have not yet been sufficiently identified. In this review, recent findings are described on the interaction between CS-DS and some proteins which are especially involved in the central nervous system and cancer development/metastasis.
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