Modulation of oxidative stress, inflammatory and apoptotic response by curcumin against cerebral ischemia reperfusion injury in a mouse model

Background: Ischemic stroke, which is a direct result of a decrease in blood flow to the mind parenchyma, is the most widely recognized reason for stroke. Objective: This assessment was endeavored to examine the neuroprotective effect of curcumin in cerebral ischemia-reperfusion harm in mice model. Materials and methods: 40 adult male Swiss albino mice (17-18) weeks of age were used randomly and were divided into four groups (10 mice in each): Group (1) sham group: In this group, the mice did not undergo a carotid occlusion. (2) control group (stroke group): the mice in this group underwent bilateral common carotid artery occlusion for 30 min. Tracked by two-hour reperfusion. Group (3) vehicle group: Mice in this group received distilled water to dissolve curcumin 30 min before the operation, then 30 min of ischemia Bilateral common carotid artery occlusion BCCAO, followed by reperfusion for 2 h. Group (4) curcumin treatment group: mice received 100 mg/kg curcumin intraperitoneal (IP). With bilateral common carotid artery occlusion for 30 min. Then reperfusion for 2 h. Results: Toward the finish of the investigation the degree of the IL-6,NF-kb,Mcp-1 Bax and F2IsoP were altogether expanded in the contro1 group as compere with sham group while fundamentally decline the degree of Bcl-2 in the control group as compere with sham group. Treatment with curcumin essentially decline the degree of IL-6,NF-kb,Mcp-1 Bax and F2IsoP in the curcumin-treated group as compare with control group while there is a critical increment in the degree of Bcl-2 in the curcumin-treated group as compared with control group. Histopathological examination showed that curcumin altogether improve the seriousness of cerebral damage in the mice experienced regular carotid artery occlusion. Conclusion: After effects of the investigation discovered that 1nflammatory cytokines, apoptosis pathways and oxidative stress are engaged with brain ischemia incited by mutual regular carotid artery block. Brain ischemia-reperfusion damage able to be changed by curcumin by means of its mitigating, hostile to apoptosis and against oxidant impacts.