Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 30, Issue -, Pages 71-78Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.01.006
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Funding
- European Molecular Biology Organization postdoctoral fellowship [ALTF 166-2012]
- Swiss National Science Foundation [310030B-152835]
- ETH [ETH-21 09-3]
- Swiss National Science Foundation (SNF) [310030B_152835] Funding Source: Swiss National Science Foundation (SNF)
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Bacterial transcription initiation is controlled by sigma factors, the RNA polymerase (RNAP) subunits responsive for promoter specificity. While the primary sigma factor ensures the bulk of transcription during growth, a major strategy used by bacteria to regulate gene expression consists of modifying the RNAP promoter specificity by means of alternative sigma factors. Among these factors, Extra Cytoplasmic Function sigma factors (sigma(ECF)) constitute the most abundant group and are generally kept inactive by specific anti-sigma factors that are directly or indirectly sensitive to environmental stimuli. When activated by anti-sigma factor release, sigma(ECF) turn on the transcription of dedicated regulons, which trigger adaptive responses for the survival of the cell. Recent structural studies have deciphered the molecular basis for sigma(ECF) promoter recognition and original regulatory mechanisms.
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