Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 31, Issue -, Pages 1-8Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.02.015
Keywords
-
Categories
Funding
- Federation of Research MSIF (Modelization, Simulations and Interaction Fundamentals)
Ask authors/readers for more resources
To fulfill the biological activities in living organisms, proteins are endowed with dynamics, robustness and adaptability. The three properties co-exist because they allow global changes in structure to arise from local perturbations (dynamics). Robustness refers to the ability of the protein to incur such changes without suffering loss of function; adaptability is the emergence of a new biological activity. Since loss of function may jeopardize the survival of the organism and lead to disease, adaptability may occur through the combination of two local perturbations that together rescue the initial function. The review highlights the relevancy of computational network analysis to understand how a local change produces global changes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available