Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 66, Issue 16, Pages 824-834Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1276061
Keywords
C-13-NMR; drug loading; functional hydrogel; glucose sensitivity; physicochemical properties
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Funding
- The World Academy of Sciences (TWAS)
- USM
- School of Materials and Mineral Resource Engineering, Universiti Sains Malaysia [FRGS-203.PBAHAN 6071337, 6071325]
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There is an urgent need to treat diabetes, and therefore, this work reports on a chitosan-built hydrogel functionalized by a glucose sensing moiety, which simulates pancreatic activity. The effect of external stimuli on various internal properties was investigated to establish the action of the hydrogel. The model drugs, fluorescein (D1) and rhodamine (D2), with a diol architecture, were investigated spectroscopically with 75.94% loading and 65.63% release. Consequently, a ligand to glucose ratio of 2:1 in comparison with a ligand to model drug ratio of 1:1 was addressed. The system was expected to lead to findings on applications for the self-controlled release of insulin in response to blood glucose levels. [GRAPHICS] .
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