Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 516, Issue 1-2, Pages 293-300Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2016.11.034
Keywords
Core-shell nanofibers; Coaxial electrospinning; Needleless electrospinning; Fluorescent spectroscopy
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Funding
- Grant Agency of Charles University [1246314, 1262414, 1228214, 545313]
- Czech Science Foundation [15-15697S]
- Ministry of Education, Youth, and Sports of the Czech Republic [NPU I:LO1508, NPU I:LO1309]
- Ministry of Interior of the Czech Republic [BV III/1-VS, VI20152018010]
- Internal Grant Agency of the Ministry of Health of the Czech Republic [NT12156, 16-29680A, 16-28637A]
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Herein, we describe a simple spinneret setup for needleless coaxial electrospinning that exceeds the limited production capacity of current approaches. The proposed weir spinneret enables coaxial electrospinning from free liquid surface. This approach leads to the formation of coaxial nanofibers with higher and uniform shell/core ratio, which results in the possibility of better tuning of the degradation rate. The throughput and quality increase favor the broader application of coaxial nanofibers from weir spinnerets as systems for controlled drug delivery in regenerative medicine and tissue engineering. (C) 2016 Elsevier B.V. All rights reserved.
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