Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 517, Issue 1-2, Pages 373-382Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2016.11.064
Keywords
Sensitivity analysis; Pharmaceutical manufacturing; Dynamic systems; Process modeling
Categories
Funding
- Austrian COMET Program by the Austrian Federal Ministry of Transport, Innovation and Technology (BMVIT)
- Austrian Federal Ministry of Economy, Family and Youth (BMWFJ)
- State of Styria (Styrian Funding Agency SFG)
Ask authors/readers for more resources
This paper presents a sensitivity analysis of a pharmaceutical direct compaction process. Sensitivity analysis is an important tool for gaining valuable process insights and designing a process control concept. Examining its results in a systematic manner makes it possible to assign actuating signals to controlled variables. This paper presents mathematical models for individual unit operations, on which the sensitivity analysis is based. Two sensitivity analysis methods are outlined: (i) based on the so-called Sobol indices and (ii) based on the steady-state gains and the frequency response of the proposed plant model. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available