Journal
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
Volume 28, Issue 2, Pages 217-225Publisher
WILEY
DOI: 10.1111/ipd.12344
Keywords
-
Categories
Funding
- National Institute of Dental and Craniofacial Research (NIDCR) [R01-DE018236, U01-DE025046]
- National Institute of Environmental Health Sciences of the National Institutes of Health [P30-ES010126]
- NIDCR [R01-DE014899, U01-DE-018903, R01-DE00955, R01-DE09551, R01-DE12101, R03-DE024264]
Ask authors/readers for more resources
ObjectiveA genetic component in early childhood caries (ECC) is theorized, but no genome-wide investigations of ECC have been conducted. This pilot study is part of a long-term research program aimed to: (1) determine the proportion of ECC variance attributable to the human genome and (2) identify ECC-associated genetic loci. MethodsThe study's community-based sample comprised 212 children (mean age=39months; range=30-52months; males=55%; Hispanic/Latino=35%, African-American=32%; American Academy of Pediatric Dentistry definition of ECC prevalence=38%). Approximately 2.4 million single nucleotide polymorphisms (SNPs) were genotyped using DNA purified from saliva. A P<5x10(-8) criterion was used for genome-wide significance. SNPs with P<5x10(-5) were followed-up in three independent cohorts of 921 preschool-age children with similar ECC prevalence. ResultsSNPs with minor allele frequency 5% explained 52% (standard error=54%) of ECC variance (one-sided P=0.03). Unsurprisingly, given the pilot's small sample size, no genome-wide significant associations were found. An intergenic locus on 4q32 (rs4690994) displayed the strongest association with ECC [P=2.3x10(-6); odds ratio (OR)=3.5; 95% confidence interval (CI)=2.1-5.9]. Thirteen loci with suggestive associations were followed-up - none showed evidence of association in the replication samples. ConclusionThis study's findings support a heritable component of ECC and demonstrate the feasibility of conducting genomics studies among preschool-age children.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available