Journal
METALLOMICS
Volume 12, Issue 6, Pages 974-987Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0mt00064g
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Funding
- Fundacao para a Ciencia e Tecnologia (FCT) [UIDB/00100/2020, PTDC/QUI-QIN/29834/2017, UID/BIO/04565/2020, PTDC/SAU/INF/29550/2017, UID/MULTI/04349/2019]
- FCT [CEE CIND/00630/2017]
- Fundação para a Ciência e a Tecnologia [PTDC/QUI-QIN/29834/2017] Funding Source: FCT
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The anticancer, antimicrobial and antiplasmodial activities of six gold(iii) bis(dithiolene) complexes were studied. Complexes1-6showed relevant anticancer properties against A2780/A2780cisR ovarian cancer cells (IC(50)values of 0.08-2 mu M), also being able to overcome cisplatin resistance in A2780cisR cells. Complex1also exhibited significant antimicrobial activity againstStaphylococcus aureus(minimum inhibitory concentration (MIC) values of 12.1 +/- 3.9 mu g mL(-1)) and bothCandida glabrataandCandida albicans(MICs of 9.7 +/- 2.7 and 19.9 +/- 2.4 mu g mL(-1), respectively). In addition, all complexes displayed antiplasmodial activity against thePlasmodium bergheiparasite liver stages, even exhibiting better results than the ones obtained using primaquine, an anti-malarial drug. Mechanistic studies support the idea that thioredoxin reductase, but not DNA, is a possible target of these complexes. Complex1is stable under biological conditions, which would be important if this compound is ever to be considered as a drug. Overall, the results obtained evidenced the promising biological activity of complex1, which might have potential as a novel anticancer, antimicrobial and antiplasmodial agent to be used as an alternative to current therapeutics.
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