Journal
CURRENT OPINION IN PHARMACOLOGY
Volume 23, Issue -, Pages 1-5Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2015.04.006
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB-650, TRR-130, FI-1238/02]
- Hertie Stiftung
- Merieux Institute
Ask authors/readers for more resources
B cells can regulate immunity negatively or positively. Identifying the B cell subsets mediating these antagonistic activities, and the molecular mechanisms governing their differentiation, might enable the development of novel approaches to target B cells therapeutically. The suppressive functions of B cells are primarily mediated through their production of interleukin (IL)-10 and IL-35. Recent studies have shown that distinct sets of IgM(+)CD19(+)CD138(hi) plasma cells were the major B cell subsets producing these cytokines in a regulatory manner in vivo during autoimmune and infectious diseases. This review summarizes current knowledge on these 'regulatory plasma cells', and discusses the emerging data showing that the mechanisms involved in their generation partly overlap with those controlling the differentiation of 'effector regulatory T cells'.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available