Journal
NEOPLASMA
Volume 67, Issue 2, Pages 286-+Publisher
AEPRESS SRO
DOI: 10.4149/neo_2019_190414N329
Keywords
osteosarcoma; microarray analysis; neoplasm metastasis
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Funding
- National Natural Science Foundation of China [81903851, 81673017, 81572188, 21502014]
- Jiangsu Province Natural Science Foundation [BK20191084, SBK2019040340, BK2012775]
- Fundamental Research Funds for the Central Universities [2242016k40152]
- Liaoning Province Natural Science Foundation [201602114]
- Research Foundation of Educational Committee of Liaoning Province [JDL2017027]
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We previously reported the presence of vasculogenic mimicry (VM) in human osteosarcoma. However, the mechanistic basis of osteosarcoma VM remains unclear. Three hundred eighty-one upregulated differentially expressed genes (DEGs) and 526 downregulated DEGs between human osteosarcoma cell line 143B and HOS cell exposed to Matrigel were screened out by microarray. GO categories such as cell adhesion, angiogenesis were enriched in 143B group. PATHWAY analysis showed enriched TGF-beta, Wnt and VEGF signaling pathway in 143B group. The hub gene ITGA2 in signal-network of DEGs exhibited pro-VM and pro-metastasis effect. Our study provides fundamental data for further studies regarding molecules involved in osteosarcoma VM.
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