Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 51, Issue 4, Pages 1271-1279Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2017.4090
Keywords
phosphatase of regenerating liver-3; colorectal cancer; IL-8; glycolysis metabolism
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Funding
- National Natural Science Foundation of Guangdong Province [2016A030313353]
- National Natural Science Foundation of China [81602539]
- International Science and Technology Cooperation Program of Guangdong Province [2013B051000025]
- Science and Technology Project of Guangdong Province [2015A050502021]
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Phosphatase of regenerating liver-3 (PRL-3) has been found to be overexpressed in liver metastases of colorectal cancer and rarely expressed in primary tumors, which plays an important role in the metastasis of colorectal cancer cells. Metabolism reprogramming has been found to be a hallmark of cancer cells, and aerobic glycolysis is a metabolic adaption for cancer cells and promotes cell proliferation. However, the association between PRL-3 and glycolysis in colorectal cancer cells is not well understood. In the present study, we explored the association between PRL-3 and glycolysis. We found that PRL-3 improved colorectal cancer cell glucose assumption, lactate production and reduced intracellular ROS levels. Besides, PRL-3 improved the expression of Glut1, HK2, PKM2 and LDHA, which are important glycolysis related molecules and enzymes. Moreover, we explored IL-8 mediated enhancement of glycolysis by PRL-3. More importantly, the proliferation and invasion of colorectal cancer cells were enhanced significantly by PRL-3 through improving glycolysis. Taken together, these results implicated the important role of PRL-3 in glycolysis metabolism through improving IL-8 secretion in colorectal cancer cells, and PRL-3 mediated glycolysis contributed to the promotion of cancer metastasis.
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