Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 51, Pages 6907-6924Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc02335c
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Funding
- National Natural Science Foundation of China [21625203, 21871126]
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The 1,n-enyne annulation reaction has emerged as one of the most powerful and straightforward tools to build carbo- and hetero-cyclic frameworks that are found in numerous natural products, pharmaceuticals and functional materials. Although the 1,n-enyne annulation methods have been well documented to date, there is a tremendous challenge with current methodologies for simultaneously incorporating external functional groups into the resulting cyclic systems. Recent advances in the radical-mediated oxidative 1,n-enyne annulation strategy involving C-H functionalization have been proven to be an ideal alternative to overcome these disadvantages. Such radical-mediated oxidative 1,n-enyne annulation can be accomplished by two different C-H functionalization modes: One proceeds through generation of the carbon-centered radicals from C-H bond direct oxidative cleavage and their subsequent addition across the C-C bond or C equivalent to C bond enabling the 1,n-enyne annulation; the other employs the C-H bonds as the radical acceptors to terminate the initial oxidative radical-triggered annulation of 1,n-enyne. In addition, during many annulation processes the inherent C-H bonds of 1,n-enynes were functionalized. Here, we summarize recent progress in radical-mediated oxidative annulations of 1,n-enynes involving two different conceptual C-H functionalization strategies and the inherent C-H functionalization with an emphasis on the scope, limitations and mechanisms of these different reactions.
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