Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 8, Issue 24, Pages 5336-5350Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb00595a
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Funding
- Natural Science Foundation of China [81660419]
- Natural Science Foundation of Ningxia [2019AAC03215, 2019AAC03210, 2018AAC03157]
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Treatment failure occurs in more than 40% of advanced nasopharyngeal carcinoma (NPC) patients including local recurrence and distant metastasis due to chemoradioresistance. Circadian clock genes were identified as regulating cancer progression and chemoradiosensitivity in a time-dependent manner. A novel nanosystem can ensure the accumulation and controllable release of chemotherapeutic agents at the tumour site at a set time. In this study, we investigated the expression of circadian clock genes and identified that period circadian regulator 2 (PER2) as a tumour suppressor plays a key role in NPC progression. A label-free proteomic approach showed thatPER2overexpression can inhibit the ERK/MAPK pathway. The chemotherapeutic effect ofPER2overexpression was assessed in NPC together with the nanosystem comprising folic acid (FA), upconverting nanoparticles covalently coupled with Rose Bengal (UCNPs-RB), 10-hydroxycamptothecin (HCPT) and lipid-perfluorohexane (PFH) (FURH-PFH-NPs).PER2overexpression combined with the targeted and controlled release of nanoagents elevated chemotherapeutic efficacy in NPC, which has potential application value for the chronotherapy of tumours.
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