Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 52, Issue 2, Pages 321-336Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2017.4214
Keywords
lung cancer; Hsp90; expression; drug target; molecular targeted therapy
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Funding
- Scientific Research Plan projects of Shaanxi Province Education Department [17JK0661]
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The exploration of the molecular mechanisms and signaling pathways on lung cancer is very important for developing new strategies of diagnosis and treatment to this disease, such as finding valuable lung cancer markers and molecularly targeted therapies. Previously, a number of studies disclose that heat shock protein 90 (Hsp90) is upregulated in cancer cells, tissues and serum of lung cancer patients, and its upregulation intimately correlates with the occurrence, development and outcome of lung cancer. On the contrary, inhibition of Hsp90 can suppress cell proliferation, motility and metastasis of lung cancer and promote apoptosis of lung cancer cells via complex signaling pathways. In addition, a series of Hsp90 inhibitors have been investigated as effective molecular targeted therapy tactics fighting against lung cancer. This review, systematically summarizes the role of Hsp90 in lung cancer, the molecular mechanisms and development of anti-Hsp90 treatment in lung cancer.
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