Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 23, Pages 4447-4451Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob00804d
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Funding
- China State Key Research [2016YEF0200503]
- National Natural Science Foundation of China [21532005]
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A facile and rapid synthesis of unsymmetrical aryl disulfides using PPh3-mediated reductive coupling of thiophenols with aryl sulfonyl chlorides was described. Good functional group tolerance and scalability were achieved in this strategy. More importantly, the approach enables the introduction of sulfonyl chlorides into the synthesis of asymmetric organic disulfides under catalyst- and base-free conditions. Using this method, unsymmetrical aromatic disulfides could be prepared from inexpensive and readily available starting materials in moderate to excellent isolated yields, through a nucleophilic substitution pathway.
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