Journal
LAB ON A CHIP
Volume 20, Issue 12, Pages 2209-2217Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0lc00191k
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Funding
- Horizon 2020 Framework Programme of the European Union [H2020-PHC-634013]
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Lab-on-chip electrokinetic focusing and separation techniques are widely used in several scientific fields. In a number of cases, these techniques have been combined with a selective analyte extraction for off-chip analysis. Nevertheless, the usability of the extracts is limited by diffusion which reduces the separation resolution. In this paper we propose the integration of a droplet generator capable of continuous or on-demand generation and extraction of electrokinetically separated and focused analytes. We demonstrate the selective droplet extraction of model analytes separated and concentratedviaion concentration polarization focusing (ICPF). We report extracted droplets with 1000-fold increased concentration. Importantly, the droplet generator does not interrupt the ICPF process making it suitable for integration with the majority of electrokinetic separation techniques.
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