Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 49, Pages 6664-6667Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc02077j
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Funding
- National Key R&D Program of China [2018YFA0902600, 2017YFA0205901]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH039, 121D11KYSB20170026, XDA16020902]
- National Science Foundation of China [21535001, 81730051, 81673039, 21761142006]
- Shenzhen Bay Laboratory [SZBL2019062801004]
- Guangdong Innovative and Entrepreneurial Research Team Program [2019ZT08Y191]
- Tencent Foundation through the XPLORER PRIZE
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We report benzeneselenol-modified gold nanoclusters (Se_Au NCs) that have significant anticancer activity by inducing autophagy and disassembly of F-actin in cancer cells. Upon treatment of different tumor models on mice, it has been found that Se_Au NCs exhibit excellent antitumor efficacy, high stability, and extremely low toxicity, which are the requirements for an ideal antineoplastic drug. Our study is a successful attempt in exploring novel anticancer agents with high biosafety.
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