4.6 Article

Nanoscopic insights into the surface conformation of neurotoxic amyloid β oligomers

Journal

RSC ADVANCES
Volume 10, Issue 37, Pages 21907-21913

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra03799k

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Funding

  1. Polish National Centre For Research And Development within the EuroNanoMed3 ERANET cofund SPEEDY project [14/EuroNanoMed/2018, 221]
  2. Tuscany Region
  3. Ministry of Foreign Affairs and International Cooperation of Italy (MAECI) through the DESWEAT project [n_KR19GR08]
  4. National Science Centre, Poland [2015/19/B/ST4/02721]
  5. Ministry of Education, Universities and Research of Italy (Progetto Dipartimento di Eccellenza Gender Medicine)

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Raman spectroscopy assisted by localized plasmon resonances generating effective hot spots at the gaps between intertwined silver nanowires is herein adopted to unravel characteristic molecular motifs on the surface of A beta(42)misfolded oligomers that are critical in driving intermolecular interactions in neurodegeneration.

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