Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 12, Issue -, Pages 1009-1018Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S108577
Keywords
iron oxide nanoparticles; magnetic hyperthermia; heat dose; nanomedicine; proliferation marker
Funding
- European Commission (MULTIFUN) [262943]
- Spanish Ministry of Economy and Competitiveness [MAT2013-47395-C4-3-R]
- Comunidad de Madrid (NANOFRONTMAG-CM) [S2013/MIT-2850]
- Ramon y Cajal subprogram [RYC-2011-09617]
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So far, the therapeutic outcome of hyperthermia has shown heterogeneous responses depending on how thermal stress is applied. We studied whether extrinsic heating (EH, hot air) and intrinsic heating (magnetic heating [MH] mediated by nanoparticles) induce distinct effects on pancreatic cancer cells (PANC-1 and BxPC-3 cells). The impact of MH (100 mu g magnetic nanoparticles [MNP]/mL; H=23.9 kA/m; f=410 kHz) was always superior to that of EH. The thermal effects were confirmed by the following observations: 1) decreased number of vital cells, 2) altered expression of pro-caspases, and 3) production of reactive oxygen species, and 4) altered mRNA expression of Ki-67, TOP2A, and TPX2. The MH treatment of tumor xenografts significantly (P <= 0.05) reduced tumor volumes. This means that different therapeutic outcomes of hyperthermia are related to the different responses cells exert to thermal stress. In particular, intratumoral MH is a valuable tool for the treatment of pancreatic cancers.
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