Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 12, Issue -, Pages 4335-4347Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S131249
Keywords
MRI visuality; chemoembolization; microfluidics; dual drugs; alginate microspheresMRI visuality; chemoembolization; microfluidics; dual drugs; alginate microspheres
Funding
- National Natural Science Foundation of China [51473057]
- National Basic Research Program of China [2012CB932500]
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Alginate microspheres loaded with superparamagnetic iron oxide nanoparticles (SPIO NPs) have been fabricated by a T-junction microfluidic device combined with an external ionic crosslinking. The obtained microspheres possess excellent visuality under magnetic resonance due to the presence of only 0.6 mg/mL SPIO NPs. The microspheres also show uniform size with narrow distribution and regular spherical shape characterized by optic microscope and environmental scanning electron microscope. Furthermore, dual drugs (5-fluorouracil and doxorubicin hydrochloride) have been loaded within the microspheres. The release behavior of dual drugs from the microspheres show typical sustained release profiles. As a novel embolic agent, such microspheres in blood vessels can be tracked by magnetic resonance scanner. Thus, the integration of embolotherapy, chemotherapy, and postoperative diagnosis can be realized.
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