Journal
BIOMATERIALS SCIENCE
Volume 8, Issue 12, Pages 3454-3471Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0bm00530d
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Funding
- Translational and Clinical Research Flagship Program of the Singapore National Research Foundation [NMRC/TCR/008-SERI/2013]
- Centre Grant Programme Optimization of Core Platform Technologies for Ocular Research (INCEPTOR) [NMRC/CG/M010/2017_SERI]
- Duke-NUS Khoo Bridge Funding Award [Duke-NUS-KBrFA/2018/0007]
- SNEC Ophthalmic Technologies Incubator Program [R1181/83/2014]
- Spanish Ministry of Economy, Industry and Competitiveness [SAF2016-76150-R]
- Lee Kong Chian School of Medicine, Nanyang Technological University Singapore Strategic Academic Initiative (SAI) Grant [L0494003]
- Agency for Science, Technology and Research (A*STAR) under its Wound Care Innovation for the Tropics (WCIT) Industry Alignment Fund Pre-Positioning (IAF-PP) grant Singapore [H17/01/a0/0K9]
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The development of antimicrobial nanofibre dressings that can protect the injured tissues from commensal pathogens while promoting tissue regeneration finds enormous potential in plastic and reconstructive surgery practices. To achieve this goal, we investigated the effect of chondroitin sulphate on the morphology, mechanical properties, wettability and biocompatibility of polydopamine crosslinked electrospun gelatin nanofibres containing mineralized magnesium. To extend the durability of dressings, we prepared composite dressings containing polycaprolactone (PCL) and gelatin as blend or core-shell nanofibres. Nanofibre blends presented greater tensile strength and stretchability, while core-shell nanofibres displayed superior photoluminescent properties. In a porcine model of cutaneous burn injury, both the blend and core-shell nanofibre dressings displayed improved re-epithelialization, wound closure and clinical outcome in comparison to untreated burns. Histology of the biopsied tissues indicated smooth regeneration and collagen organization of the burns treated with core-shell nanostructures than untreated burns. This study compared the physico-chemical and biological properties of composite nanofibres that are capable of accelerating burn wound healing and possess antimicrobial properties, highlighting their potential as wound dressings and skin substitutes.
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