Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ijms18030548
Keywords
spinal cord injury; neurotrophic factors; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neuroprotection; plasticity; regeneration
Funding
- Shriners Hospitals for Pediatric Research (grant SHC) [84050, 8520]
- Department of Defense [SC140089]
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Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and neurotransmitter release, and elicit the plasticity and growth of axons within the adult central and peripheral nervous system. Since the 1950s, these factors have been extensively studied in traumatic injury models. Here we review several members of the classical family of neurotrophins, the receptors they bind to, and their contribution to axonal regeneration and sprouting of sensory and motor pathways after spinal cord injury (SCI). We focus on nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), and their effects on populations of neurons within diverse spinal tracts. Understanding the cellular targets of neurotrophins and the responsiveness of specific neuronal populations will allow for the most efficient treatment strategies in the injured spinal cord.
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