Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms18122540
Keywords
programmed death-ligand 1 (PD-L1); programmed death 1(PD-1); microRNAs; immune checkpoint
Funding
- International S&T Cooperation Program of China [2016YFE0121900]
- Scientific Research Innovation Team Construction Program of Fujian Normal University [IRTL1702]
- United Fujian Provincial Health & Education Project for Tackling the Key Research [WKJ2016-2-27]
- Natural Science Foundation of Fujian Province [2016Y0029]
- Science and Technology Development Fund of Macau SAR [FDCT 023/2015/AMJ]
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Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs have gained more attention as an important new layer of molecular regulation. Recent studies have revealed that altered expression of microRNAs play a pivotal role in immune checkpoint and various cellular processes in cancer. In this review, we focused on the latest progress about microRNAs research which involves the regulation of PD-1/PD-L1 immune checkpoint.
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