Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms18050984
Keywords
advanced glycation end-products; diabetes; glyoxalase; aldose reductase; methylglyoxal; glyoxal; 3-deoxyglucosone
Funding
- Deutsche Forschungsgemeinschaft (DFG) [SFB1118]
- Dietmar Hopp Foundation (DHS)
- German Center for Diabetes Research (DZD)
Ask authors/readers for more resources
Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available