Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ijms18071599
Keywords
uncoupling protein 2 (UCP2); sirtuin 3 (SIRT3); peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1 alpha); oxidative stress; cerebral ischemia/reperfusion injury; mitochondria
Funding
- National Natural Science Foundation of China [81672948, 81472419]
- Jilin Provincial Research Foundation for International Science and Technology Cooperation Projects, China [20160414005GH, 20170623093-03TC]
- Jilin University Bethune [2015222]
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Recovered blood supply after cerebral ischemia for a certain period of time fails to restore brain function, with more severe dysfunctional problems developing, called cerebral ischemia-reperfusion injury (CIR). CIR involves several extremely complex pathophysiological processes in which the interactions between key factors at various stages have not been fully elucidated. Mitochondrial dysfunction is one of the most important mechanisms of CIR. The mitochondrial deacetylase, sirtuin 3 (SIRT3), can inhibit mitochondrial oxidative stress by deacetylation, to maintain mitochondrial stability. Uncoupling protein 2 (UCP2) regulates ATP (Adenosine triphosphate) and reactive oxygen species production by affecting the mitochondrial respiratory chain, which may play a protective role in CIR. Finally, we propose that UCP2 regulates the activity of SIRT3 through sensing the energy level and, in turn, maintaining the mitochondrial steady state, which demonstrates a cytoprotective effect on CIR.
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