Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ijms18071375
Keywords
miR-3648; endoplasmic reticulum stress; Adenomatous polyposis coli 2; proliferation; Wnt
Funding
- National Basic Research Program of China [2015CB943000]
- National Natural Science Foundation of China [31471225]
- Development Foundation of Hefei Center for Physical Science and Technology [2016FXCX006]
- CAS Key Laboratory of Innate Immunity and Chronic Disease [KLIICD-201603]
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MicroRNAs (miRNAs) play important roles under multiple cellular conditions including endoplasmic reticulum (ER) stress. We found that miR-3648, a human specific microRNA, was induced under ER stress. Moreover, Adenomatous polyposis coli 2 (APC2), a tumor suppressor and a negative regulator of Wnt signaling, was found to be the direct target of miR-3648. Levels of APC2 were downregulated when cells were under ER stress or after overexpressing miR-3648. Inhibition of miR-3648 by antagomir increased APC2 levels and decreased cell proliferation. Conversely, when miR-3648 was overexpressed, APC2 levels were decreased and the cell growth increased. Our data demonstrated that ER stress mediated induction of miR-3648 in human cells, which then downregulated APC2 to increase cell proliferation.
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