Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 1, Pages -Publisher
MDPI AG
DOI: 10.3390/ijms18010168
Keywords
6-paradol; shogaols; 3T3-L1 adipocytes; C2C12 myotubes; high-fat diet-fed mice; diabetes mellitus
Funding
- National Science Council, Taiwan [NSC 102-2628-B-037-003-MY3, MOST 103-2320-B-037-005-MY2, NSC 101-2314-B-037-033, NSC 102-2314-B-037-017]
- Kaohsiung Medical University [KMU-TP103D07, KMU-TP103D20, KMU-TP103A21]
Ask authors/readers for more resources
The anti-diabetic activity of ginger powder (Zingiber officinale) has been recently promoted, with the recommendation to be included as one of the dietary supplements for diabetic patients. However, previous studies presented different results, which may be caused by degradation and metabolic changes of ginger components, gingerols, shogaols and paradols. Therefore, we prepared 10 ginger active components, namely 6-, 8-, 10-paradols, 6-, 8-, 10-shogaols, 6-, 8-, 10-gingerols and zingerone, and evaluated their anti-hyperglycemic activity. Among the tested compounds, 6-paradol and 6-shogaol showed potent activity in stimulating glucose utilization by 3T3-L1 adipocytes and C2C12 myotubes. The effects were attributed to the increase in 5 0 adenosine monophosphate-activated protein kinase (AMPK) phosphorylation in 3T3-L1 adipocytes. 6-Paradol, the major metabolite of 6-shogaol, was utilized in an in vivo assay and significantly reduced blood glucose, cholesterol and body weight in high-fat diet-fed mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available