4.6 Article

Highly efficient enrichment ofN-glycopeptides by two-dimensional Hf-based metal-organic framework nanosheets

Journal

ANALYST
Volume 145, Issue 13, Pages 4432-4435

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d0an00647e

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Funding

  1. National Natural Science Foundation of China [81473391, 81303277]
  2. Natural Science Foundation of Jiangsu Province of China [BK20190086]
  3. Priority Academic Program Development of Jiangsu Higher Education Institutions

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Highly efficient enrichment of target glycopeptides plays a crucial role in glycoproteome research. Owing to their large surface area and excellent hydrophilicity, 2-D Hf-BTB nanosheets showed effective and selective enrichment of 78 glycopeptides derived from 29 glycoproteins with 90N-glycosylation sites from just 2 mu L of human serum.

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