Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms18112401
Keywords
cognitive impairment; Spirulina maxima 70% ethanol extract (SM70EE); amyloid precursor protein (APP) processing; oxidative stress; glycogen synthase kinase-3 beta (GSK-3)
Ask authors/readers for more resources
Spirulina maxima, a microalga containing high levels of protein and many polyphenols, including chlorophyll a and C-phycocyanin, has antioxidant and anti-inflammatory therapeutic effects. However, the mechanisms where by Spirulina maxima ameliorates cognitive disorders induced by amyloid-beta 1-42 (A beta(1-42)) are not fully understood. In this study, we investigated whether a 70% ethanol extract of Spirulina maxima (SM70EE) ameliorated cognitive impairments induced by an intracerebroventricular injection of A beta(1-42) in mice. SM70EE increased the step-through latency time in the passive avoidance test and decreased the escape latency time in the Morris water maze test in A beta(1-42)-injected mice. SM70EE reduced hippocampal A beta(1-42) levels and inhibited amyloid precursor protein processing-associated factors in A beta(1-42)-injected mice. Additionally, acetylcholinesterase activity was suppressed by SM70EE in A beta(1-42)-injected mice. Hippocampal glutathione levels were examined to determine the effects of SM70EE on oxidative stress in A beta(1-42)-injected mice. SM70EE increased the levels of glutathione and its associated factors that were reduced in A beta(1-42)-injected mice. SM70EE also promoted activation of the brain-derived neurotrophic factor/phosphatidylinositol-3 kinase/serine/threonine protein kinase signaling pathway and inhibited glycogen synthase kinase-3 phosphorylation. These findings suggested that SM70EE ameliorated A beta(1-42)-induced cognitive impairments by inhibiting the increased phosphorylation of glycogen synthase kinase-3 caused by intracerebroventricular injection of A beta(1-42) in mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available