Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ijms18040739
Keywords
neurogenesis; resilience; inflammation; pain; neuropsychiatric disorders
Funding
- German Research Foundation (DFG) via the collaborative research center [1080, A3]
- DFG [SCHM 2159/4-1]
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Increasing evidence demonstrates the importance of hippocampal neurogenesis, a fundamental mechanism of neuroplasticity associated with cognition and emotion, in correlation to neurodegenerative and psychiatric disorders. Neuropsychiatric disorders are often a result of chronic stress or pain followed by inflammation; all these conditions manifest cognitive deficits and impairments in neurogenesis. However, while some individuals are more susceptible to stress, others are able to adapt to new environments via mechanisms of resilience. In light of this emerging field and based on extensive research, the role of neurogenesis is summarized and presented as a potentially powerful therapeutic tool.
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