Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms18112399
Keywords
silver nanoparticles; hydrogel; cashew gum; healing; wounds; antibacterial activity
Funding
- CNPq [400398/2014-1]
- Fundacao para a Ciencia e a Tecnologia (MCTES funds) [SFRH/BD/95983/2013]
- European Union (FSE funds) [SFRH/BD/95983/2013]
- European Union (FEDER funds through COMPETE program)
- National Funds (FCT) [UID/QUI/50006/2013-POCI-01-0145-FEDER-007265, NORTE-01-0145-FEDER-000011]
- FCT [SFRH/BD/97995/2013]
- POPH-QREN-Tipologia 4.1-Formacao Avancada - Fundo Social Europeu and Ministerio da Ciencia, Tecnologia e Ensino Superior
- Fundação para a Ciência e a Tecnologia [SFRH/BD/95983/2013] Funding Source: FCT
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Silver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles. The nanoparticles were prepared in the hydrogel in situ, utilizing two variants of cashew gum as a capping agent, and sodium borohydride as the reducing agent. This gum is non-toxic and comes from a renewable natural source. The particles and gel were thoroughly characterized through using rheological measurements, UV-vis spectroscopy, nanoparticles tracking analysis, and transmission electron microscopy analysis (TEM). Antibacterial tests were carried out, confirming antimicrobial action of the silver nanoparticle-loaded gels. Furthermore, rat wound-healing models were used and demonstrated that the gels exhibited improved wound healing when compared to the base hydrogel as a control. Thus, these gels are proposed as excellent candidates for use as wound-healing treatments.
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