Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ijms18102207
Keywords
microtubule dynamics; post-translational modifications; acetylation; glutamylation; glycylation; methylation; phosphorylation; polyamination
Funding
- National Science Centre, Poland, Harmonia 6 [2014/14/M/NZ3/00511]
- Polish Academy of Sciences
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Microtubules are hollow tube-like polymeric structures composed of alpha,beta-tubulin heterodimers. They play an important role in numerous cellular processes, including intracellular transport, cell motility and segregation of the chromosomes during cell division. Moreover, microtubule doublets or triplets form a scaffold of a cilium, centriole and basal body, respectively. To perform such diverse functions microtubules have to differ in their properties. Post-translational modifications are one of the factors that affect the properties of the tubulin polymer. Here we focus on the direct and indirect effects of post-translational modifications of tubulin on microtubule dynamics.
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