Related references
Note: Only part of the references are listed.Therapeutic targeting and patient selection for cancers with homologous recombination defects
Francien Talens et al.
EXPERT OPINION ON DRUG DISCOVERY (2017)
Chromatin dynamics during the cell cycle at centromeres
Sebastian Mueller et al.
NATURE REVIEWS GENETICS (2017)
Telomeres in cancer: tumour suppression and genome instability
John Maciejowski et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
The SWI/SNF ATP-dependent nucleosome remodeler promotes resection initiation at a DNA double-strand break in yeast
Nathaniel E. Wiest et al.
NUCLEIC ACIDS RESEARCH (2017)
A global view of meiotic double-strand break end resection
Eleni P. Mimitou et al.
SCIENCE (2017)
The Rb1 tumour suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression
I. Gonzalez-Vasconcellos et al.
SCIENTIFIC REPORTS (2017)
Genomic Instability in Cancer: Teetering on the Limit of Tolerance
Noemi Andor et al.
CANCER RESEARCH (2017)
The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals
Gohei Nishibuchi et al.
CHROMOSOME RESEARCH (2017)
Endogenous DNA Damage as a Source of Genomic Instability in Cancer
Anthony Tubbs et al.
CELL (2017)
LINEs in mice: features, families, and potential roles in early development
Joanna W. Jachowicz et al.
CHROMOSOMA (2016)
RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1
Renier Velez-Cruz et al.
GENES & DEVELOPMENT (2016)
RB1: a prototype tumor suppressor and an enigma
Nicholas J. Dyson
GENES & DEVELOPMENT (2016)
An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences
Charles A. Ishak et al.
MOLECULAR CELL (2016)
Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly
Xuan Li et al.
ELIFE (2016)
SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases
Gwendolyn Bennett et al.
DNA REPAIR (2015)
Targeting the DNA Damage Response in Cancer
Mark J. O'Connor
MOLECULAR CELL (2015)
ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
Jianfeng Shen et al.
CANCER DISCOVERY (2015)
Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining
Rebecca Cook et al.
CELL REPORTS (2015)
E2F1 Responds to Ultraviolet Radiation by Directly Stimulating DNA Repair and Suppressing Carcinogenesis
Anup Kumar Biswas et al.
CANCER RESEARCH (2014)
TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways
Christopher P. Wardlaw et al.
DNA REPAIR (2014)
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
Anthony J. Davis et al.
DNA REPAIR (2014)
Function of transcription factors at DNA lesions in DNA repair
Michal Malewicz et al.
EXPERIMENTAL CELL RESEARCH (2014)
Suppression of Genome Instability in pRB-Deficient Cells by Enhancement of Chromosome Cohesion
Amity L. Manning et al.
MOLECULAR CELL (2014)
Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor
Simon M. Carr et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Cyclin D activates the Rb tumor suppressor by mono-phosphorylation
Anil M. Narasimha et al.
ELIFE (2014)
Chromatin Remodeling at DNA Double-Strand Breaks
Brendan D. Price et al.
CELL (2013)
To trim or not to trim Progression and control of DSB end resection
Magda Granata et al.
CELL CYCLE (2013)
PP1 and PP2A phosphatases - cooperating partners in modulating retinoblastoma protein activation
Victoria Kolupaeva et al.
FEBS JOURNAL (2013)
The retinoblastoma protein induces apoptosis directly at the mitochondria
Keren I. Hilgendorf et al.
GENES & DEVELOPMENT (2013)
Arginine Methylation-Dependent Reader-Writer Interplay Governs Growth Control by E2F-1
Shunsheng Zheng et al.
MOLECULAR CELL (2013)
Molecular mechanisms underlying RB protein function
Frederick A. Dick et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Repair of Strand Breaks by Homologous Recombination
Maria Jasin et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Genomic Instability in Cancer
Tarek Abbas et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
End-joining, translocations and cancer
Samuel F. Bunting et al.
NATURE REVIEWS CANCER (2013)
Histone marks: repairing DNA breaks within the context of chromatin
Kyle M. Miller et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2012)
Transcriptional and Nontranscriptional Functions of E2F1 in Response to DNA Damage
Anup K. Biswas et al.
CANCER RESEARCH (2012)
Chromosome instability and deregulated proliferation: an unavoidable duo
Courtney H. Coschi et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2012)
Phosphorylation puts the pRb tumor suppressor into shape
Andreas M. F. Heilmann et al.
GENES & DEVELOPMENT (2012)
The retinoblastoma tumor suppressor and stem cell biology
Julien Sage
GENES & DEVELOPMENT (2012)
Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control
Jason R. Burke et al.
GENES & DEVELOPMENT (2012)
E2F1 and p53 Transcription Factors as Accessory Factors for Nucleotide Excision Repair
Renier Velez-Cruz et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
DNA Damage Signals through Differentially Modified E2F1 Molecules To Induce Apoptosis
Jasmyne Carnevale et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Diversity within the pRb pathway: is there a code of conduct?
S. Munro et al.
ONCOGENE (2012)
GENOMIC INSTABILITY IN CANCER - OPINION RB: mitotic implications of a tumour suppressor
Amity L. Manning et al.
NATURE REVIEWS CANCER (2012)
The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein
Matthew J. Cecchini et al.
BIOCHEMICAL JOURNAL (2011)
Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression
Colleen A. Brady et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks
Jie Chen et al.
CELL CYCLE (2011)
Newly identified aspects of tumor suppression by RB
Patrick Viatour et al.
DISEASE MODELS & MECHANISMS (2011)
DNA end resection-Unraveling the tail
Eleni P. Mimitou et al.
DNA REPAIR (2011)
Adenovirus E1A Directly Targets the E2F/DP-1 Complex
Peter Pelka et al.
JOURNAL OF VIROLOGY (2011)
GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage
Ruifeng Guo et al.
NUCLEIC ACIDS RESEARCH (2011)
Transcriptional Activation by pRB and Its Coordination with SWI/SNF Recruitment
Stephen Flowers et al.
CANCER RESEARCH (2010)
PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers
Craig P. Carden et al.
CURRENT OPINION IN ONCOLOGY (2010)
Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive
Courtney H. Coschi et al.
GENES & DEVELOPMENT (2010)
Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling
Tanja van Harn et al.
GENES & DEVELOPMENT (2010)
Loss of pRB causes centromere dysfunction and chromosomal instability
Amity L. Manning et al.
GENES & DEVELOPMENT (2010)
E2F1 Localizes to Sites of UV-induced DNA Damage to Enhance Nucleotide Excision Repair
Ruifeng Guo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Phosphorylation-induced Conformational Changes in the Retinoblastoma Protein Inhibit E2F Transactivation Domain Binding
Jason R. Burke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
A G1 Checkpoint Mediated by the Retinoblastoma Protein That Is Dispensable in Terminal Differentiation but Essential for Senescence
Srikanth Talluri et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Telomeres: protecting chromosomes against genome instability
Roderick J. O'Sullivan et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
Kyle M. Miller et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein
Alessandra Ianari et al.
CANCER CELL (2009)
The role of the retinoblastoma/E2F1 tumor suppressor pathway in the lesion recognition step of nucleotide excision repair
Patrick S. Lin et al.
DNA REPAIR (2009)
hSirT1-Dependent Regulation of the PCAF-E2F1-p73 Apoptotic Pathway in Response to DNA Damage
Natalia Pediconi et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3
Michelle S. Longworth et al.
GENES & DEVELOPMENT (2008)
Conserved functions of the pRB and E2F families
Sander van den Heuvel et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
E2F-at the crossroads of life and death
Shirley Polager et al.
TRENDS IN CELL BIOLOGY (2008)
Tailoring to RB: tumour suppressor status and therapeutic response
Erik S. Knudsen et al.
NATURE REVIEWS CANCER (2008)
Cellular mechanisms of tumour suppression by the retinoblastoma gene
Deborah L. Burkhart et al.
NATURE REVIEWS CANCER (2008)
Human CtIP promotes DNA end resection
Alessandro A. Sartori et al.
NATURE (2007)
Transposable elements and the epigenetic regulation of the genome
R. Keith Slotkin et al.
NATURE REVIEWS GENETICS (2007)
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
Chuangui Wang et al.
NATURE CELL BIOLOGY (2006)
The retinoblastoma protein regulates pericentric heterochromatin
CE Isaac et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
DNA-damage-responsive acetylation of pRb regulates binding to E2F-1
D Markham et al.
EMBO REPORTS (2006)
Role of Rb family in the epigenetic definition of chromatin
S Gonzalo et al.
CELL CYCLE (2005)
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
JH Lee et al.
SCIENCE (2005)
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
S Gonzalo et al.
NATURE CELL BIOLOGY (2005)
TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival
K Liu et al.
GENES & DEVELOPMENT (2004)
A role for 14-3-3τ in E2F1 stabilization and DNA damage-induced apoptosis
B Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2Factivities
FA Dick et al.
MOLECULAR CELL (2003)
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
L Zou et al.
SCIENCE (2003)
Regulation of E2F1 by BRCT domain-containing protein TopBP1
K Liu et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
A role for the Rb family of proteins in controlling telomere length
M García-Cao et al.
NATURE GENETICS (2002)
Sibling rivalry in the E2F family
JM Trimarchi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
E2F transcriptional activation requires TRRAP and GCN5 cofactors
SE Lang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Acetylation control of the retinoblastoma tumour-suppressor protein
HM Chan et al.
NATURE CELL BIOLOGY (2001)
Initial sequencing and analysis of the human genome
ES Lander et al.
NATURE (2001)
Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization
J Sage et al.
GENES & DEVELOPMENT (2000)