Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 18, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ijms18030608
Keywords
non-coding RNA; microRNA; long non-coding RNA; circular RNA; cardiac remodeling
Funding
- Shandong Provincial Natural Science Foundation of China [ZR2016HB30]
- Qingdao Postdoctoral Application Research Funded Project [2015143]
- China Postdoctoral Science Foundation [2016M592132]
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Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins. Studies show that ncRNAs are not only involved in cell proliferation, apoptosis, differentiation, metabolism and other physiological processes, but also involved in the pathogenesis of diseases. Cardiac remodeling is the main pathological basis of a variety of cardiovascular diseases. Many studies have shown that the occurrence and development of cardiac remodeling are closely related with the regulation of ncRNAs. Recent research of ncRNAs in heart disease has achieved rapid development. Thus, we summarize here the latest research progress and mainly the molecular mechanism of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), in cardiac remodeling, aiming to look for new targets for heart disease treatment.
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